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Saturation Mutagenesis by Efficient Free-Energy Calculation
[Image: see text] Single-point mutations in proteins can greatly influence protein stability, binding affinity, protein function or its expression per se. Here, we present accurate and efficient predictions of the free energy of mutation of amino acids. We divided the complete mutational free energy...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813279/ https://www.ncbi.nlm.nih.gov/pubmed/29262673 http://dx.doi.org/10.1021/acs.jctc.7b01099 |