Folic acid derived-P5779 mimetics regulate DAMP-mediated inflammation through disruption of HMGB1:TLR4:MD-2 axes

High mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) protein that mediates inflammatory responses after infection or injury. Previously, we reported a peptide inhibitor of HMGB1 (P5779) that acts by directly interrupting HMGB1/MD-2 binding. Here, fingerprint similarity s...

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Detalles Bibliográficos
Autores principales: Sun, Shan, He, Mingzhu, Wang, Yongjun, Yang, Huan, Al-Abed, Yousef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814057/
https://www.ncbi.nlm.nih.gov/pubmed/29447234
http://dx.doi.org/10.1371/journal.pone.0193028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814057/
https://www.ncbi.nlm.nih.gov/pubmed/29447234
http://dx.doi.org/10.1371/journal.pone.0193028

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