Ras/ERK-signalling promotes tRNA synthesis and growth via the RNA polymerase III repressor Maf1 in Drosophila

The small G-protein Ras is a conserved regulator of cell and tissue growth. These effects of Ras are mediated largely through activation of a canonical RAF-MEK-ERK kinase cascade. An important challenge is to identify how this Ras/ERK pathway alters cellular metabolism to drive growth. Here we repor...

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Detalles Bibliográficos
Autores principales: Sriskanthadevan-Pirahas, Shrivani, Deshpande, Rujuta, Lee, Byoungchun, Grewal, Savraj S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814106/
https://www.ncbi.nlm.nih.gov/pubmed/29401457
http://dx.doi.org/10.1371/journal.pgen.1007202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814106/
https://www.ncbi.nlm.nih.gov/pubmed/29401457
http://dx.doi.org/10.1371/journal.pgen.1007202

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