Inhibition of the NEDD8 conjugation pathway induces calcium-dependent compensatory activation of the pro-survival MEK/ERK pathway in acute lymphoblastic leukemia

De novo and acquired drug resistance and subsequent relapse remain major challenges in acute lymphoblastic leukemia (ALL). We previously identified that pevonedistat (TAK-924, MLN4924), a first-in-class inhibitor of NEDD8 activating enzyme (NAE), elicits ER stress and has potent in vitro and in vivo...

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Detalles Bibliográficos
Autores principales: Zheng, Shuhua, Leclerc, Gilles M., Li, Bin, Swords, Ronan T., Barredo, Julio C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814156/
https://www.ncbi.nlm.nih.gov/pubmed/29464016
http://dx.doi.org/10.18632/oncotarget.23797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814156/
https://www.ncbi.nlm.nih.gov/pubmed/29464016
http://dx.doi.org/10.18632/oncotarget.23797

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