Activation of p53 and destabilization of androgen receptor by combinatorial inhibition of MDM2 and MDMX in prostate cancer cells

Castration-resistant prostate cancer (CRPC) frequently develops after initial standard radiation and androgen deprivation therapy, leaving patients with limited further treatment options. Androgen receptor (AR) is a transcription factor that plays a key role in the initiation and progression of pros...

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Detalles Bibliográficos
Autores principales: Chopra, Harman, Khan, Zara, Contreras, Jamie, Wang, Herui, Sedrak, Abanob, Zhu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814211/
https://www.ncbi.nlm.nih.gov/pubmed/29464071
http://dx.doi.org/10.18632/oncotarget.23569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814211/
https://www.ncbi.nlm.nih.gov/pubmed/29464071
http://dx.doi.org/10.18632/oncotarget.23569

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