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SIRT1 increases cardiomyocyte binucleation in the heart development
SIRT1 regulates cell senescence. We investigated a novel role of SIRT1 in the regulation of cardiomyocyte terminal differentiation in the developing heart. Retinoic acid (RA)-induced binucleation of H9c2 cells was associated with increased SIRT1 expression. Inhibition of SIRT1 activity or expression...
Autores principales: | Shin, Alexandra N., Han, Limin, Dasgupta, Chiranjib, Huang, Lei, Yang, Shumei, Zhang, Lubo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814276/ https://www.ncbi.nlm.nih.gov/pubmed/29487709 http://dx.doi.org/10.18632/oncotarget.23847 |
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