Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer’s disease model mice

Granulin (Grn) mutations were identified in familial frontotemporal lobar degeneration (FTLD) patients with TAR DNA-binding protein of 43 kd (TDP-43) pathology. Grn transcript haploinsufficiency is proposed as a disease mechanism that leads to the loss of functional progranulin (PGRN) protein. Thus,...

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Detalles Bibliográficos
Autores principales: Hosokawa, Masato, Tanaka, Yoshinori, Arai, Tetsuaki, Kondo, Hiromi, Akiyama, Haruhiko, Hasegawa, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2017
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814315/
https://www.ncbi.nlm.nih.gov/pubmed/28845019
http://dx.doi.org/10.1538/expanim.17-0060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814315/
https://www.ncbi.nlm.nih.gov/pubmed/28845019
http://dx.doi.org/10.1538/expanim.17-0060

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