Effects of ketoconazole on cyclophosphamide metabolism: evaluation of CYP3A4 inhibition effect using the in vitro and in vivo models

Cyclophosphamide (CP) is widely used in anticancer therapy regimens and 2-dechloroethylcyclophosphamide (DECP) is its side-chain dechloroethylated metabolite. N-dechloroethylation of CP mediated by the enzyme CYP3A4 yields nephrotoxic and neurotoxic chloroacetaldehyde (CAA) in equimolar amount to DE...

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Detalles Bibliográficos
Autores principales: Yang, Le, Yan, Chenyang, Zhang, Feng, Jiang, Bo, Gao, Shouhong, Liang, Youtian, Huang, Lifeng, Chen, Wansheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2017
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814316/
https://www.ncbi.nlm.nih.gov/pubmed/29129847
http://dx.doi.org/10.1538/expanim.17-0048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814316/
https://www.ncbi.nlm.nih.gov/pubmed/29129847
http://dx.doi.org/10.1538/expanim.17-0048

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