Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation

Elevated O-GlcNAcylation is associated with disease states such as diabetes and cancer. O-GlcNAc transferase (OGT) is elevated in multiple cancers and inhibition of this enzyme genetically or pharmacologically inhibits oncogenesis. Here we show that O-GlcNAcylation modulates lipid metabolism in canc...

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Detalles Bibliográficos
Autores principales: Sodi, Valerie L., Bacigalupa, Zachary A., Ferrer, Christina M., Lee, Joyce V., Gocal, Wiktoria A., Mukhopadhyay, Dimpi, Wellen, Kathryn E., Ivan, Mircea, Reginato, Mauricio J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814337/
https://www.ncbi.nlm.nih.gov/pubmed/29059153
http://dx.doi.org/10.1038/onc.2017.395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814337/
https://www.ncbi.nlm.nih.gov/pubmed/29059153
http://dx.doi.org/10.1038/onc.2017.395

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