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Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation

Elevated O-GlcNAcylation is associated with disease states such as diabetes and cancer. O-GlcNAc transferase (OGT) is elevated in multiple cancers and inhibition of this enzyme genetically or pharmacologically inhibits oncogenesis. Here we show that O-GlcNAcylation modulates lipid metabolism in canc...

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Detalles Bibliográficos
Autores principales:	Sodi, Valerie L., Bacigalupa, Zachary A., Ferrer, Christina M., Lee, Joyce V., Gocal, Wiktoria A., Mukhopadhyay, Dimpi, Wellen, Kathryn E., Ivan, Mircea, Reginato, Mauricio J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814337/ https://www.ncbi.nlm.nih.gov/pubmed/29059153 http://dx.doi.org/10.1038/onc.2017.395

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