Recombinant Human PH20: Baseline Analysis of the Reactive Antibody Prevalence in the General Population Using Healthy Subjects

BACKGROUND: Recombinant human PH20 (rHuPH20) is used to depolymerize hyaluronan in the subcutaneous space, increasing the dispersion and absorption of co-administered drugs. While ~ 5 to 10% of rHuPH20 treatment-naïve healthy volunteers have demonstrated rHuPH20-reactive antibodies, associations wit...

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Detalles Bibliográficos
Autores principales: Rosengren, Sanna, Souratha, Jennifer, Conway, Dave, Muchmore, Douglas B., Sugarman, Barry J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814530/
https://www.ncbi.nlm.nih.gov/pubmed/29442293
http://dx.doi.org/10.1007/s40259-018-0260-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814530/
https://www.ncbi.nlm.nih.gov/pubmed/29442293
http://dx.doi.org/10.1007/s40259-018-0260-y

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