Two‐phase designs for joint quantitative‐trait‐dependent and genotype‐dependent sampling in post‐GWAS regional sequencing

We evaluate two‐phase designs to follow‐up findings from genome‐wide association study (GWAS) when the cost of regional sequencing in the entire cohort is prohibitive. We develop novel expectation‐maximization‐based inference under a semiparametric maximum likelihood formulation tailored for post‐GW...

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Detalles Bibliográficos
Autores principales: Espin‐Garcia, Osvaldo, Craiu, Radu V., Bull, Shelley B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814750/
https://www.ncbi.nlm.nih.gov/pubmed/29239496
http://dx.doi.org/10.1002/gepi.22099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814750/
https://www.ncbi.nlm.nih.gov/pubmed/29239496
http://dx.doi.org/10.1002/gepi.22099

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