Phage Display on the Anti‐infective Target 1‐Deoxy‐d‐xylulose‐5‐phosphate Synthase Leads to an Acceptor–Substrate Competitive Peptidic Inhibitor

Enzymes of the 2‐C‐methyl‐d‐erythritol‐4‐phosphate pathway for the biosynthesis of isoprenoid precursors are validated drug targets. By performing phage display on 1‐deoxy‐d‐xylulose‐5‐phosphate synthase (DXS), which catalyzes the first step of this pathway, we discovered several peptide hits and re...

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Detalles Bibliográficos
Autores principales: Marcozzi, Alessio, Masini, Tiziana, Zhu, Di, Pesce, Diego, Illarionov, Boris, Fischer, Markus, Herrmann, Andreas, Hirsch, Anna K. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814854/
https://www.ncbi.nlm.nih.gov/pubmed/29119720
http://dx.doi.org/10.1002/cbic.201700402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814854/
https://www.ncbi.nlm.nih.gov/pubmed/29119720
http://dx.doi.org/10.1002/cbic.201700402

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