Accuracy of genetic code translation and its orthogonal corruption by aminoglycosides and Mg(2+) ions

We studied the effects of aminoglycosides and changing Mg(2+) ion concentration on the accuracy of initial codon selection by aminoacyl-tRNA in ternary complex with elongation factor Tu and GTP (T(3)) on mRNA programmed ribosomes. Aminoglycosides decrease the accuracy by changing the equilibrium con...

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Detalles Bibliográficos
Autores principales: Zhang, Jingji, Pavlov, Michael Y, Ehrenberg, Måns
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814885/
https://www.ncbi.nlm.nih.gov/pubmed/29267976
http://dx.doi.org/10.1093/nar/gkx1256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814885/
https://www.ncbi.nlm.nih.gov/pubmed/29267976
http://dx.doi.org/10.1093/nar/gkx1256

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