The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial

Inhibition of apoptosis signal–regulating kinase 1, a serine/threonine kinase, leads to improvement in inflammation and fibrosis in animal models of nonalcoholic steatohepatitis. We evaluated the safety and efficacy of selonsertib, a selective inhibitor of apoptosis signal–regulating kinase 1, alone...

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Detalles Bibliográficos
Autores principales: Loomba, Rohit, Lawitz, Eric, Mantry, Parvez S., Jayakumar, Saumya, Caldwell, Stephen H., Arnold, Hays, Diehl, Anna Mae, Djedjos, C. Stephen, Han, Ling, Myers, Robert P., Subramanian, G. Mani, McHutchison, John G., Goodman, Zachary D., Afdhal, Nezam H., Charlton, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814892/
https://www.ncbi.nlm.nih.gov/pubmed/28892558
http://dx.doi.org/10.1002/hep.29514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814892/
https://www.ncbi.nlm.nih.gov/pubmed/28892558
http://dx.doi.org/10.1002/hep.29514

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