Single-molecule DNA unzipping reveals asymmetric modulation of a transcription factor by its binding site sequence and context

Most functional transcription factor (TF) binding sites deviate from their ‘consensus’ recognition motif, although their sites and flanking sequences are often conserved across species. Here, we used single-molecule DNA unzipping with optical tweezers to study how Egr-1, a TF harboring three zinc fi...

Descripción completa

Detalles Bibliográficos
Autores principales: Rudnizky, Sergei, Khamis, Hadeel, Malik, Omri, Squires, Allison H, Meller, Amit, Melamed, Philippa, Kaplan, Ariel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815098/
https://www.ncbi.nlm.nih.gov/pubmed/29253225
http://dx.doi.org/10.1093/nar/gkx1252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815098/
https://www.ncbi.nlm.nih.gov/pubmed/29253225
http://dx.doi.org/10.1093/nar/gkx1252

Ejemplares similares