Cargando…
Single-molecule DNA unzipping reveals asymmetric modulation of a transcription factor by its binding site sequence and context
Most functional transcription factor (TF) binding sites deviate from their ‘consensus’ recognition motif, although their sites and flanking sequences are often conserved across species. Here, we used single-molecule DNA unzipping with optical tweezers to study how Egr-1, a TF harboring three zinc fi...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815098/ https://www.ncbi.nlm.nih.gov/pubmed/29253225 http://dx.doi.org/10.1093/nar/gkx1252 |