Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription

The yeast RNA/DNA helicase Sen1, Senataxin in human, preserves the integrity of replication forks encountering transcription by removing RNA-DNA hybrids. Here we show that, in sen1 mutants, when a replication fork clashes head-on with transcription is arrested and, as a consequence, the progression...

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Detalles Bibliográficos
Autores principales: Brambati, Alessandra, Zardoni, Luca, Achar, Yathish Jagadheesh, Piccini, Daniele, Galanti, Lorenzo, Colosio, Arianna, Foiani, Marco, Liberi, Giordano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815123/
https://www.ncbi.nlm.nih.gov/pubmed/29059325
http://dx.doi.org/10.1093/nar/gkx945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815123/
https://www.ncbi.nlm.nih.gov/pubmed/29059325
http://dx.doi.org/10.1093/nar/gkx945

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