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Derivative-free neural network for optimizing the scoring functions associated with dynamic programming of pairwise-profile alignment

BACKGROUND: A profile-comparison method with position-specific scoring matrix (PSSM) is among the most accurate alignment methods. Currently, cosine similarity and correlation coefficients are used as scoring functions of dynamic programming to calculate similarity between PSSMs. However, it is uncl...

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Detalles Bibliográficos
Autor principal: Yamada, Kazunori D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815186/
https://www.ncbi.nlm.nih.gov/pubmed/29467815
http://dx.doi.org/10.1186/s13015-018-0123-6