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Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons

In Alzheimer disease and related disorders, the microtubule-associated protein tau aggregates and forms cytoplasmic lesions that impair neuronal physiology at many levels. In addition to affecting the host neuron, tau aggregates also spread to neighboring, recipient cells where the misfolded tau agg...

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Detalles Bibliográficos
Autores principales: Polanco, Juan Carlos, Li, Chuanzhou, Durisic, Nela, Sullivan, Robert, Götz, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815204/
https://www.ncbi.nlm.nih.gov/pubmed/29448966
http://dx.doi.org/10.1186/s40478-018-0514-4