In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome
RATIONALE: The prevalence of Alzheimer’s disease is increased in people with Down syndrome. The pathology appears much earlier than in the general population, suggesting a predisposition to develop Alzheimer’s disease. Down syndrome results from trisomy of human chromosome 21, leading to overexpress...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815426/ https://www.ncbi.nlm.nih.gov/pubmed/29215943 http://dx.doi.org/10.1177/0269881117743484 |