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In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome

RATIONALE: The prevalence of Alzheimer’s disease is increased in people with Down syndrome. The pathology appears much earlier than in the general population, suggesting a predisposition to develop Alzheimer’s disease. Down syndrome results from trisomy of human chromosome 21, leading to overexpress...

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Detalles Bibliográficos
Autores principales:	Naert, Gaëlle, Ferré, Valentine, Keller, Emeline, Slender, Amy, Gibbins, Dorota, Fisher, Elizabeth MC, Tybulewicz, Victor LJ, Maurice, Tangui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2017
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815426/ https://www.ncbi.nlm.nih.gov/pubmed/29215943 http://dx.doi.org/10.1177/0269881117743484

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