Genome editing reveals a role for OCT4 in human embryogenesis

Despite their fundamental biological and clinical importance, the molecular mechanisms that regulate the first cell fate decisions in the human embryo are not well understood. Here we use CRISPR–Cas9-mediated genome editing to investigate the function of the pluripotency transcription factor OCT4 du...

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Detalles Bibliográficos
Autores principales: Fogarty, Norah M. E., McCarthy, Afshan, Snijders, Kirsten E., Powell, Benjamin E., Kubikova, Nada, Blakeley, Paul, Lea, Rebecca, Elder, Kay, Wamaitha, Sissy E., Kim, Daesik, Maciulyte, Valdone, Kleinjung, Jens, Kim, Jin-Soo, Wells, Dagan, Vallier, Ludovic, Bertero, Alessandro, Turner, James M. A., Niakan, Kathy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815497/
https://www.ncbi.nlm.nih.gov/pubmed/28953884
http://dx.doi.org/10.1038/nature24033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815497/
https://www.ncbi.nlm.nih.gov/pubmed/28953884
http://dx.doi.org/10.1038/nature24033

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