Surrogate Wnt agonists that phenocopy canonical Wnt/β-catenin signaling

Wnts modulate cell proliferation, differentiation and stem cell self-renewal, by inducing β-catenin dependent signaling through Frizzled (Fzd) and Lrp5/6 to regulate cell fate decisions, and the growth and repair of a multitude of tissues(1). The 19 mammalian Wnts interact promiscuously with the 10...

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Detalles Bibliográficos
Autores principales: Janda, Claudia Y., Dang, Luke T., You, Changjiang, Chang, Junlei, de Lau, Wim, Zhong, Zhendong A., Yan, Kelley S., Marecic, Owen, Siepe, Dirk, Li, Xingnan, Moody, James D., Williams, Bart O., Clevers, Hans, Piehler, Jacob, Baker, David, Kuo, Calvin J., Garcia, K. Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815871/
https://www.ncbi.nlm.nih.gov/pubmed/28467818
http://dx.doi.org/10.1038/nature22306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815871/
https://www.ncbi.nlm.nih.gov/pubmed/28467818
http://dx.doi.org/10.1038/nature22306

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