Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4

Obesity, a prevalent condition in adults and children, impairs bone marrow (BM) function. However, the underlying mechanisms are unclear. Here, we show that obese mice exhibit poor emergency immune responses in a toll-like receptor 4 (TLR4)-dependent manner. Canonical myeloid genes (Csf1r, Spi1, Run...

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Detalles Bibliográficos
Autores principales: Liu, Ailing, Chen, Minhui, Kumar, Rashmi, Stefanovic-Racic, Maja, O’Doherty, Robert M., Ding, Ying, Jahnen-Dechent, Willi, Borghesi, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816016/
https://www.ncbi.nlm.nih.gov/pubmed/29453396
http://dx.doi.org/10.1038/s41467-018-03145-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816016/
https://www.ncbi.nlm.nih.gov/pubmed/29453396
http://dx.doi.org/10.1038/s41467-018-03145-8

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