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Physical basis of amyloid fibril polymorphism

Polymorphism is a key feature of amyloid fibril structures but it remains challenging to explain these variations for a particular sample. Here, we report electron cryomicroscopy-based reconstructions from different fibril morphologies formed by a peptide fragment from an amyloidogenic immunoglobuli...

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Detalles Bibliográficos
Autores principales: Close, William, Neumann, Matthias, Schmidt, Andreas, Hora, Manuel, Annamalai, Karthikeyan, Schmidt, Matthias, Reif, Bernd, Schmidt, Volker, Grigorieff, Nikolaus, Fändrich, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816019/
https://www.ncbi.nlm.nih.gov/pubmed/29453354
http://dx.doi.org/10.1038/s41467-018-03164-5