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Microglia Polarization, Gene-Environment Interactions and Wnt/β-Catenin Signaling: Emerging Roles of Glia-Neuron and Glia-Stem/Neuroprogenitor Crosstalk for Dopaminergic Neurorestoration in Aged Parkinsonian Brain

Neuroinflammatory processes are recognized key contributory factors in Parkinson's disease (PD) physiopathology. While the causes responsible for the progressive loss of midbrain dopaminergic (mDA) neuronal cell bodies in the subtantia nigra pars compacta are poorly understood, aging, genetics,...

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Detalles Bibliográficos
Autores principales: L'Episcopo, Francesca, Tirolo, Cataldo, Serapide, Maria F., Caniglia, Salvatore, Testa, Nunzio, Leggio, Loredana, Vivarelli, Silvia, Iraci, Nunzio, Pluchino, Stefano, Marchetti, Bianca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816064/
https://www.ncbi.nlm.nih.gov/pubmed/29483868
http://dx.doi.org/10.3389/fnagi.2018.00012