Cargando…
Method to generate highly stable D-amino acid analogs of bioactive helical peptides using a mirror image of the entire PDB
Biologics are a rapidly growing class of therapeutics with many advantages over traditional small molecule drugs. A major obstacle to their development is that proteins and peptides are easily destroyed by proteases and, thus, typically have prohibitively short half-lives in human gut, plasma, and c...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816147/ https://www.ncbi.nlm.nih.gov/pubmed/29378946 http://dx.doi.org/10.1073/pnas.1711837115 |