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RNA force field with accuracy comparable to state-of-the-art protein force fields

Molecular dynamics (MD) simulation has become a powerful tool for characterizing at an atomic level of detail the conformational changes undergone by proteins. The application of such simulations to RNA structures, however, has proven more challenging, due in large part to the fact that the physical...

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Detalles Bibliográficos
Autores principales: Tan, Dazhi, Piana, Stefano, Dirks, Robert M., Shaw, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816156/
https://www.ncbi.nlm.nih.gov/pubmed/29378935
http://dx.doi.org/10.1073/pnas.1713027115