Optimized peptide based inhibitors targeting the dihydrofolate reductase pathway in cancer

We report the first peptide based hDHFR inhibitors designed on the basis of structural analysis of dihydrofolate reductase (DHFR). A set of peptides were rationally designed and synthesized using solid phase peptide synthesis and characterized using nuclear magnetic resonance and enzyme immunoassays...

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Detalles Bibliográficos
Autores principales: Singh, Amrinder, Deshpande, Neha, Pramanik, Nilkamal, Jhunjhunwala, Siddharth, Rangarajan, Annapoorni, Atreya, Hanudatta S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816602/
https://www.ncbi.nlm.nih.gov/pubmed/29453377
http://dx.doi.org/10.1038/s41598-018-21435-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816602/
https://www.ncbi.nlm.nih.gov/pubmed/29453377
http://dx.doi.org/10.1038/s41598-018-21435-5

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