Autophagy in Negative-Strand RNA Virus Infection

Autophagy is a homoeostatic process by which cytoplasmic material is targeted for degradation by the cell. Viruses have learned to manipulate the autophagic pathway to ensure their own replication and survival. Although much progress has been achieved in dissecting the interplay between viruses and...

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Autores principales: Wang, Yupeng, Jiang, Ke, Zhang, Quan, Meng, Songshu, Ding, Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816943/
https://www.ncbi.nlm.nih.gov/pubmed/29487586
http://dx.doi.org/10.3389/fmicb.2018.00206
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author Wang, Yupeng
Jiang, Ke
Zhang, Quan
Meng, Songshu
Ding, Chan
author_facet Wang, Yupeng
Jiang, Ke
Zhang, Quan
Meng, Songshu
Ding, Chan
author_sort Wang, Yupeng
collection PubMed
description Autophagy is a homoeostatic process by which cytoplasmic material is targeted for degradation by the cell. Viruses have learned to manipulate the autophagic pathway to ensure their own replication and survival. Although much progress has been achieved in dissecting the interplay between viruses and cellular autophagic machinery, it is not well understood how the cellular autophagic pathway is utilized by viruses and manipulated to their own advantage. In this review, we briefly introduce autophagy, viral xenophagy and the interaction among autophagy, virus and immune response, then focus on the interplay between NS-RNA viruses and autophagy during virus infection. We have selected some exemplary NS-RNA viruses and will describe how these NS-RNA viruses regulate autophagy and the role of autophagy in NS-RNA viral replication and in immune responses to virus infection. We also review recent advances in understanding how NS-RNA viral proteins perturb autophagy and how autophagy-related proteins contribute to NS-RNA virus replication, pathogenesis and antiviral immunity.
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spelling pubmed-58169432018-02-27 Autophagy in Negative-Strand RNA Virus Infection Wang, Yupeng Jiang, Ke Zhang, Quan Meng, Songshu Ding, Chan Front Microbiol Microbiology Autophagy is a homoeostatic process by which cytoplasmic material is targeted for degradation by the cell. Viruses have learned to manipulate the autophagic pathway to ensure their own replication and survival. Although much progress has been achieved in dissecting the interplay between viruses and cellular autophagic machinery, it is not well understood how the cellular autophagic pathway is utilized by viruses and manipulated to their own advantage. In this review, we briefly introduce autophagy, viral xenophagy and the interaction among autophagy, virus and immune response, then focus on the interplay between NS-RNA viruses and autophagy during virus infection. We have selected some exemplary NS-RNA viruses and will describe how these NS-RNA viruses regulate autophagy and the role of autophagy in NS-RNA viral replication and in immune responses to virus infection. We also review recent advances in understanding how NS-RNA viral proteins perturb autophagy and how autophagy-related proteins contribute to NS-RNA virus replication, pathogenesis and antiviral immunity. Frontiers Media S.A. 2018-02-13 /pmc/articles/PMC5816943/ /pubmed/29487586 http://dx.doi.org/10.3389/fmicb.2018.00206 Text en Copyright © 2018 Wang, Jiang, Zhang, Meng and Ding. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Wang, Yupeng
Jiang, Ke
Zhang, Quan
Meng, Songshu
Ding, Chan
Autophagy in Negative-Strand RNA Virus Infection
title Autophagy in Negative-Strand RNA Virus Infection
title_full Autophagy in Negative-Strand RNA Virus Infection
title_fullStr Autophagy in Negative-Strand RNA Virus Infection
title_full_unstemmed Autophagy in Negative-Strand RNA Virus Infection
title_short Autophagy in Negative-Strand RNA Virus Infection
title_sort autophagy in negative-strand rna virus infection
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816943/
https://www.ncbi.nlm.nih.gov/pubmed/29487586
http://dx.doi.org/10.3389/fmicb.2018.00206
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AT dingchan autophagyinnegativestrandrnavirusinfection