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From Chemotherapy to Combined Targeted Therapeutics: In Vitro and in Vivo Models to Decipher Intra-tumor Heterogeneity

Recent advances in next-generation sequencing and other omics technologies capable to map cell fate provide increasing evidence on the crucial role of intra-tumor heterogeneity (ITH) for cancer progression. The different facets of ITH, from genomic to microenvironmental heterogeneity and the hierarc...

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Detalles Bibliográficos
Autores principales:	Gambara, Guido, Gaebler, Manuela, Keilholz, Ulrich, Regenbrecht, Christian R. A., Silvestri, Alessandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817069/ https://www.ncbi.nlm.nih.gov/pubmed/29491834 http://dx.doi.org/10.3389/fphar.2018.00077

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