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Oligopeptide Targeting Sortase A as Potential Anti-infective Therapy for Staphylococcus aureus

Sortase A (SrtA)-catalyzed anchorage of surface proteins in most Gram-positive bacteria is indispensable for their virulence, suggesting that this transpeptidase is a promising target for antivirulence therapy. Here, an oligopeptide, LPRDA, was identified as an effective inhibitor of SrtA via virtua...

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Detalles Bibliográficos
Autores principales:	Wang, Jianfeng, Li, Hongen, Pan, Juan, Dong, Jing, Zhou, Xuan, Niu, Xiaodi, Deng, Xuming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817083/ https://www.ncbi.nlm.nih.gov/pubmed/29491861 http://dx.doi.org/10.3389/fmicb.2018.00245

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