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Characterization of feedback-resistant mevalonate kinases from the methanogenic archaeons Methanosaeta concilii and Methanocella paludicola

The inhibition of mevalonate kinase (MVK) by downstream metabolites is an important mechanism in the regulation of isoprenoid production in a broad range of organisms. The first feedback-resistant MVK was previously discovered in the methanogenic archaeon Methanosarcinamazei. Here, we report the clo...

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Detalles Bibliográficos
Autores principales: Kazieva, Ekaterina, Yamamoto, Yoko, Tajima, Yoshinori, Yokoyama, Keiichi, Katashkina, Joanna, Nishio, Yousuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817203/
https://www.ncbi.nlm.nih.gov/pubmed/28869407
http://dx.doi.org/10.1099/mic.0.000510