Optimization of lentiviral vector production for scale-up in fixed-bed bioreactor

Lentiviral vectors (LVs) are promising tools for gene therapy. However, scaling up the production methods of LVs in order to produce high-quality vectors for clinical purposes has proven to be difficult. In this article, we present a scalable and efficient method to produce LVs with transient transf...

Descripción completa

Detalles Bibliográficos
Autores principales: Valkama, A J, Leinonen, H M, Lipponen, E M, Turkki, V, Malinen, J, Heikura, T, Ylä-Herttuala, S, Lesch, H P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817386/
https://www.ncbi.nlm.nih.gov/pubmed/29345252
http://dx.doi.org/10.1038/gt.2017.91

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817386/
https://www.ncbi.nlm.nih.gov/pubmed/29345252
http://dx.doi.org/10.1038/gt.2017.91

Ejemplares similares