Increasing BMI is associated with reduced expression of P-glycoprotein (ABCB1 gene) in the human brain with a stronger association in African Americans than Caucasians

The efflux pump, p-glycoprotein, controls bioavailability and excretion of pharmaceutical compounds. In the blood–brain barrier, p-glycoprotein regulates the delivery of pharmaceutical substances to the brain, influencing efficacy and side effects for some drugs notably antipsychotics. Common side e...

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Detalles Bibliográficos
Autores principales: Vendelbo, J, Olesen, R H, Lauridsen, J K, Rungby, J, Kleinman, J E, Hyde, T M, Larsen, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817387/
https://www.ncbi.nlm.nih.gov/pubmed/27897267
http://dx.doi.org/10.1038/tpj.2016.74

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817387/
https://www.ncbi.nlm.nih.gov/pubmed/27897267
http://dx.doi.org/10.1038/tpj.2016.74

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