A New Mechanism for β‐Lactamases: Class D Enzymes Degrade 1β‐Methyl Carbapenems through Lactone Formation

β‐Lactamases threaten the clinical use of carbapenems, which are considered antibiotics of last resort. The classical mechanism of serine carbapenemase catalysis proceeds through hydrolysis of an acyl‐enzyme intermediate. We show that class D β‐lactamases also degrade clinically used 1β‐methyl‐subst...

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Detalles Bibliográficos
Autores principales: Lohans, Christopher T., van Groesen, Emma, Kumar, Kiran, Tooke, Catherine L., Spencer, James, Paton, Robert S., Brem, Jürgen, Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817396/
https://www.ncbi.nlm.nih.gov/pubmed/29236332
http://dx.doi.org/10.1002/anie.201711308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817396/
https://www.ncbi.nlm.nih.gov/pubmed/29236332
http://dx.doi.org/10.1002/anie.201711308

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