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Targeting few to help hundreds: JAK, MAPK and ROCK pathways as druggable targets in atypical chronic myeloid leukemia

Atypical Chronic Myeloid Leukemia (aCML) is a myeloproliferative neoplasm characterized by neutrophilic leukocytosis and dysgranulopoiesis. From a genetic point of view, aCML shows a heterogeneous mutational landscape with mutations affecting signal transduction proteins but also broad genetic modif...

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Detalles Bibliográficos
Autores principales:	Rocca, Stefania, Carrà, Giovanna, Poggio, Pietro, Morotti, Alessandro, Brancaccio, Mara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817721/ https://www.ncbi.nlm.nih.gov/pubmed/29455651 http://dx.doi.org/10.1186/s12943-018-0774-4

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