Combined treatment with a selective PDE10A inhibitor TAK‐063 and either haloperidol or olanzapine at subeffective doses produces potent antipsychotic‐like effects without affecting plasma prolactin levels and cataleptic responses in rodents

Activation of indirect pathway medium spiny neurons (MSNs) via promotion of cAMP production is the principal mechanism of action of current antipsychotics with dopamine D(2) receptor antagonism. TAK‐063 [1‐[2‐fluoro‐4‐(1H‐pyrazol‐1‐yl)phenyl]‐5‐methoxy‐3‐(1‐phenyl‐1H‐pyrazol‐5‐yl)pyridazin‐4(1H)‐one...

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Detalles Bibliográficos
Autores principales: Suzuki, Kazunori, Harada, Akina, Suzuki, Hirobumi, Capuani, Clizia, Ugolini, Annarosa, Corsi, Mauro, Kimura, Haruhide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817828/
https://www.ncbi.nlm.nih.gov/pubmed/29417763
http://dx.doi.org/10.1002/prp2.372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817828/
https://www.ncbi.nlm.nih.gov/pubmed/29417763
http://dx.doi.org/10.1002/prp2.372

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