Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling

Originally identified as a metabolic enzyme that catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP in the glycolytic pathway, pyruvate kinase M2-type (PKM2) has been shown to exhibit novel biological activities in the nucleus and outside the cells. Although cell-based...

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Detalles Bibliográficos
Autores principales: Hsu, Ming-Chuan, Hung, Wen-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817853/
https://www.ncbi.nlm.nih.gov/pubmed/29455645
http://dx.doi.org/10.1186/s12943-018-0791-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817853/
https://www.ncbi.nlm.nih.gov/pubmed/29455645
http://dx.doi.org/10.1186/s12943-018-0791-3

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