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The force-dependent mechanism of DnaK-mediated mechanical folding

It is well established that chaperones modulate the protein folding free-energy landscape. However, the molecular determinants underlying chaperone-mediated mechanical folding remain largely elusive, primarily because the force-extended unfolded conformation fundamentally differs from that character...

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Detalles Bibliográficos
Autores principales: Perales-Calvo, Judit, Giganti, David, Stirnemann, Guillaume, Garcia-Manyes, Sergi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817926/
https://www.ncbi.nlm.nih.gov/pubmed/29487911
http://dx.doi.org/10.1126/sciadv.aaq0243