Gli3 in fetal thymic epithelial cells promotes thymocyte positive selection and differentiation by repression of Shh

Gli3 is a Hedgehog (Hh)-responsive transcription factor that can function as a transcriptional repressor or activator. We show that Gli3 activity in mouse thymic epithelial cells (TECs) promotes positive selection and differentiation from CD4(+) CD8(+) to CD4(+) CD8(−) single-positive (SP4) cells in...

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Detalles Bibliográficos
Autores principales: Solanki, Anisha, Yanez, Diana C., Ross, Susan, Lau, Ching-In, Papaioannou, Eleftheria, Li, Jiawei, Saldaña, José Ignacio, Crompton, Tessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817998/
https://www.ncbi.nlm.nih.gov/pubmed/29361554
http://dx.doi.org/10.1242/dev.146910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817998/
https://www.ncbi.nlm.nih.gov/pubmed/29361554
http://dx.doi.org/10.1242/dev.146910

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