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Gli3 in fetal thymic epithelial cells promotes thymocyte positive selection and differentiation by repression of Shh
Gli3 is a Hedgehog (Hh)-responsive transcription factor that can function as a transcriptional repressor or activator. We show that Gli3 activity in mouse thymic epithelial cells (TECs) promotes positive selection and differentiation from CD4(+) CD8(+) to CD4(+) CD8(−) single-positive (SP4) cells in...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Ltd
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817998/ https://www.ncbi.nlm.nih.gov/pubmed/29361554 http://dx.doi.org/10.1242/dev.146910 |