Cargando…

Adjunct zonisamide to levodopa for DLB parkinsonism: A randomized double-blind phase 2 study

OBJECTIVE: To investigate the efficacy and safety of zonisamide as an adjunct to levodopa therapy for parkinsonism in patients with dementia with Lewy bodies (DLB). METHODS: This phase 2, placebo-controlled, randomized, double-blind study consisted of run-in (placebo, 4 weeks) and treatment (placebo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Murata, Miho, Odawara, Toshinari, Hasegawa, Kazuko, Iiyama, Sayaka, Nakamura, Masatoshi, Tagawa, Masaaki, Kosaka, Kenji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818167/ https://www.ncbi.nlm.nih.gov/pubmed/29367449 http://dx.doi.org/10.1212/WNL.0000000000005010

Ejemplares similares

Efficacy and Safety of Zonisamide in Dementia with Lewy Bodies Patients with Parkinsonism: A Post Hoc Analysis of Two Randomized, Double-Blind, Placebo-Controlled Trials
por: Hasegawa, Kazuko, et al.
Publicado: (2021)

Zonisamide Enhances Motor Effects of Levodopa, Not of Apomorphine, in a Rat Model of Parkinson's Disease
por: Nishijima, Haruo, et al.
Publicado: (2018)

Comparative whole transcriptome analysis of Parkinson’s disease focusing on the efficacy of zonisamide
por: Naito, Tatsuhiko, et al.
Publicado: (2022)

Zonisamide Efficacy as Adjunctive Therapy in Children With Refractory Epilepsy
por: KARIMZADEH, Parvaneh, et al.
Publicado: (2013)

Genome-wide association study identifies zonisamide responsive gene in Parkinson’s disease patients
por: Cha, Pei-Chieng, et al.
Publicado: (2020)

Accuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers: a study by the Italian DLB study group (DLB-SINdem)
por: Russo, Mirella, et al.
Publicado: (2022)

Efficacy of Adjunctive Therapy with Zonisamide Versus Increased Dose of Levodopa for Motor Symptoms in Patients with Dementia with Lewy Bodies: The Randomized, Controlled, Non-Inferiority DUEL Study
por: Ikeda, Manabu, et al.
Publicado: (2023)

Comparative Efficacy of Zonisamide and Pregabalin as an Adjunctive Therapy in Children with Refractory Epilepsy
por: TAGHDIRI, Mohammad Mahdi, et al.
Publicado: (2015)

Long-term treatment of Parkinson’s disease with levodopa and other adjunctive drugs
por: Mizuno, Yoshikuni, et al.
Publicado: (2017)

Zonisamide for the Treatment of Parkinson Disease: A Current Update
por: Li, Chengqian, et al.
Publicado: (2020)

Zonisamide Ameliorates Microglial Mitochondriopathy in Parkinson’s Disease Models
por: Tada, Satoshi, et al.
Publicado: (2022)

Efficacy and safety of levodopa–carbidopa intestinal gel from a study in Japanese, Taiwanese, and Korean advanced Parkinson’s disease patients
por: Murata, Miho, et al.
Publicado: (2016)

Spotlight on opicapone as an adjunct to levodopa in Parkinson’s disease: design, development and potential place in therapy
por: Annus, Ádám, et al.
Publicado: (2017)

Rasagiline as Adjunct to Levodopa for Treatment of Parkinson's Disease: A Systematic Review and Meta-Analysis
por: Kano, Osamu, et al.
Publicado: (2022)

Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB
por: Yan, Run, et al.
Publicado: (2018)

Nightmare-Enacting Behavior Responding to Zonisamide in Early Parkinson's Disease
por: Kataoka, Hiroshi, et al.
Publicado: (2012)

Zonisamide effects on sleep problems and depressive symptoms in Parkinson’s disease
por: Suzuki, Keisuke, et al.
Publicado: (2021)

Safety and efficacy of levodopa-carbidopa intestinal gel: results from an open-label extension study in Japanese, Korean and Taiwanese patients with advanced Parkinson’s disease
por: Murata, Miho, et al.
Publicado: (2018)

Long-term safety and efficacy of adjunctive rasagiline in levodopa-treated Japanese patients with Parkinson’s disease
por: Hattori, Nobutaka, et al.
Publicado: (2019)

Comparative efficacy and safety of adjunctive drugs to levodopa for fluctuating Parkinson’s disease - network meta-analysis
por: Sako, Wataru, et al.
Publicado: (2023)

Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology
por: Fujita, Kyota, et al.
Publicado: (2018)

Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson’s Disease
por: Ueno, Shin-Ichi, et al.
Publicado: (2018)

Polysomnographic and Clinical Parameters before and after Zonisamide Therapy for Parkinson's Disease
por: Miyaue, Noriyuki, et al.
Publicado: (2022)

Zonisamide improves axial symptoms in dementia with Lewy bodies with parkinsonism: Post hoc analysis of clinical trials()
por: Tsuboi, Yoshio, et al.
Publicado: (2021)

Introduction of an assessment toolkit associated with increased rate of DLB diagnosis
por: Surendranathan, A., et al.
Publicado: (2021)

Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium
por: McKeith, Ian G., et al.
Publicado: (2017)

Zonisamide: A review of the clinical and experimental evidence for its use in Parkinson's disease
por: Grover, Neeta D., et al.
Publicado: (2013)

Zonisamide in the management of epilepsy in the elderly
por: Romigi, Andrea, et al.
Publicado: (2015)

Gender Differences in Levodopa Pharmacokinetics in Levodopa-Naïve Patients With Parkinson’s Disease
por: Conti, Valeria, et al.
Publicado: (2022)

REM Sleep Behavior Disorder (RBD) in Dementia with Lewy Bodies (DLB)
por: Chan, Po-Chi, et al.
Publicado: (2018)

FDG PET metabolic signatures distinguishing prodromal DLB and prodromal AD
por: Kantarci, Kejal, et al.
Publicado: (2021)

Fact‐finding survey on diagnostic procedures and therapeutic interventions for parkinsonism accompanying dementia with Lewy bodies
por: Manabe, Yuta, et al.
Publicado: (2019)

Levodopa/carbidopa microtablets in Parkinson’s disease: a study of pharmacokinetics and blinded motor assessment
por: Senek, Marina, et al.
Publicado: (2017)

Behavioral effects of zonisamide on L-DOPA-induced dyskinesia in Parkinson's disease model mice
por: Sano, Hiromi, et al.
Publicado: (2023)

Impact of Pregnancy on Zonisamide Pharmacokinetics in Rabbits
por: Matar, Kamal M.
Publicado: (2013)

Repositioning again of zonisamide for nerve regeneration
por: Ohno, Kinji, et al.
Publicado: (2016)

Zonisamide-induced acute kidney injury
por: Dixit, Deepali, et al.
Publicado: (2015)

Efficacy of Zonisamide in Migraineurs with Nonresponse to Topiramate
por: Chung, Jin-Young, et al.
Publicado: (2014)

Zonisamide-Induced Hallucinations: An Anticonvulsant’s Psychosis
por: Al Armashi, Abdul Rahman, et al.
Publicado: (2021)

Continuous levodopa for advanced Parkinson’s disease
por: Lundqvist, Christofer
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_0hn03eue73bele5k89i39nkhhb