Adenosine A2A receptor agonist ameliorates EAE and correlates with Th1 cytokine‐induced blood brain barrier dysfunction via suppression of MLCK signaling pathway

INTRODUCTION: Multiple sclerosis (MS) disease activity is associated with blood‐brain barrier (BBB) disruption, which is mediated by inflammatory cytokines released by CD4+ lymphocytes. To assess the effects of adenosine A2A receptors on BBB permeability in vitro and in vivo. METHODS: A2A receptor e...

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Detalles Bibliográficos
Autores principales: Liu, Ying, Alahiri, Marwan, Ulloa, Bianca, Xie, Boxun, Sadiq, Saud A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818446/
https://www.ncbi.nlm.nih.gov/pubmed/29027376
http://dx.doi.org/10.1002/iid3.187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818446/
https://www.ncbi.nlm.nih.gov/pubmed/29027376
http://dx.doi.org/10.1002/iid3.187

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