Use of HuH6 and other human-derived hepatoma lines for the detection of genotoxins: a new hope for laboratory animals?

Cell lines which are currently used in genotoxicity tests lack enzymes which activate/detoxify mutagens. Therefore, rodent-derived liver preparations are used which reflect their metabolism in humans only partly; as a consequence misleading results are often obtained. Previous findings suggest that...

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Detalles Bibliográficos
Autores principales: Waldherr, Monika, Mišík, Miroslav, Ferk, Franziska, Tomc, Jana, Žegura, Bojana, Filipič, Metka, Mikulits, Wolfgang, Mai, Sören, Haas, Oskar, Huber, Wolfgang W., Haslinger, Elisabeth, Knasmüller, Siegfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Genotoxicity and Carcinogenicity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818615/
https://www.ncbi.nlm.nih.gov/pubmed/29218508
http://dx.doi.org/10.1007/s00204-017-2109-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818615/
https://www.ncbi.nlm.nih.gov/pubmed/29218508
http://dx.doi.org/10.1007/s00204-017-2109-4

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