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Involvement of impaired autophagy and mitophagy in Neuro-2a cell damage under hypoxic and/or high-glucose conditions

Chronic cerebral hypoperfusion (CCH) plays an insidious role in the development of cognitive impairment. Considerable evidence suggests that Diabetes Mellitus (DM) as a vascular risk factor may exacerbate CCH and is closely related to cognitive decline. Dysregulation of autophagy is known to be asso...

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Detalles Bibliográficos
Autores principales: Song, Yufei, Du, Yu, Zou, Wenying, Luo, Yan, Zhang, Xiaojie, Fu, Jianliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818622/
https://www.ncbi.nlm.nih.gov/pubmed/29459731
http://dx.doi.org/10.1038/s41598-018-20162-1