Benchmark dose analyses of multiple genetic toxicity endpoints permit robust, cross-tissue comparisons of MutaMouse responses to orally delivered benzo[a]pyrene

Genetic damage is a key event in tumorigenesis, and chemically induced genotoxic effects are a human health concern. Although genetic toxicity data have historically been interpreted using a qualitative screen-and-bin approach, there is increasing interest in quantitative analysis of genetic toxicit...

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Detalles Bibliográficos
Autores principales: Long, Alexandra S., Wills, John W., Krolak, Dorothy, Guo, Matthew, Dertinger, Stephen D., Arlt, Volker M., White, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Genotoxicity and Carcinogenicity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818629/
https://www.ncbi.nlm.nih.gov/pubmed/29177888
http://dx.doi.org/10.1007/s00204-017-2099-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818629/
https://www.ncbi.nlm.nih.gov/pubmed/29177888
http://dx.doi.org/10.1007/s00204-017-2099-2

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