Consequences of SPAK inactivation on Hyperkalemic Hypertension caused by WNK1 mutations: evidence for differential roles of WNK1 and WNK4

Mutations of the gene encoding WNK1 [With No lysine (K) kinase 1] or WNK4 cause Familial Hyperkalemic Hypertension (FHHt). Previous studies have shown that the activation of SPAK (Ste20-related Proline/Alanine-rich Kinase) plays a dominant role in the development of FHHt caused by WNK4 mutations. Th...

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Detalles Bibliográficos
Autores principales: Rafael, Chloé, Soukaseum, Christelle, Baudrie, Véronique, Frère, Perrine, Hadchouel, Juliette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818654/
https://www.ncbi.nlm.nih.gov/pubmed/29459793
http://dx.doi.org/10.1038/s41598-018-21405-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818654/
https://www.ncbi.nlm.nih.gov/pubmed/29459793
http://dx.doi.org/10.1038/s41598-018-21405-x

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