Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine‐based inhibitor co‐crystal structure

The membrane protein interacting with kinase C1 (PICK1) plays a trafficking role in the internalization of neuron receptors such as the amino‐3‐hydroxyl‐5‐methyl‐4‐isoxazole‐propionate (AMPA) receptor. Reduction of surface AMPA type receptors on neurons reduces synaptic communication leading to cogn...

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Detalles Bibliográficos
Autores principales: Marcotte, Douglas J., Hus, Jean‐Christophe, Banos, Charles C., Wildes, Craig, Arduini, Robert, Bergeron, Chris, Hession, Catherine A., Baker, Darren P., Lin, Edward, Guckian, Kevin M., Dunah, Anthone W., Silvian, Laura F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818740/
https://www.ncbi.nlm.nih.gov/pubmed/29280296
http://dx.doi.org/10.1002/pro.3361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818740/
https://www.ncbi.nlm.nih.gov/pubmed/29280296
http://dx.doi.org/10.1002/pro.3361

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